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Suppression of adjuvant-induced arthritis in da rats by incomplete freund's adjuvant

✍ Scribed by Grant W. Cannon; Marie M. Griffiths; Marion L. Woods

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
431 KB
Volume
36
Category
Article
ISSN
0004-3591

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✦ Synopsis

Objective. To define the effects of incomplete Freund's adjuvant (LCFA) on subsequent arthritis induced by complete Freund's adjuvant (CFA) and type I1 collagen (CII) in DA and Lewis rats.

Methods. ICFA was injected into DA and Lewis rats before CFA or CII injection.

Results. DA rats previously injected with ICFA had significantly less severe arthritis induced by CFA compared with those not receiving ICFA pretreatment (P < 0.01). ICFA had no significant impact on CFAinduced arthritis in Lewis rats or on CII-induced arthritis in DA rats.

Conclusion. The injection of ICFA alone specifically suppresses subsequent CFA-induced arthritis in DA rats, but not in Lewis rats.

DA rats injected with incomplete Freund's adjuvant (ICFA) alone develop a mild transient arthritis not seen in other rat strains (1). W e describe herein our From the Salt Lake City Veterans Affairs Medical Center and the Divisions of

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