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Histidine residues at the N- and C-termini of .alpha.-helixes: perturbed pKas and protein stability

✍ Scribed by Sancho, Javier; Serrano, Luis; Fersht, Alan R.


Book ID
126918032
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
741 KB
Volume
31
Category
Article
ISSN
0006-2960

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## Synopsis An estimation of the thermodynamic effects of a charged random coil, which is attached either to the Nor C-terminus of polyalanine, upon a-helix stability is attempted. A temperature induced helix-coil transition of Ala,Lys,Phe and Lys,Ala,Phe was studied under various conditions of sa