Histamine in the immune regulation of allergic inflammation
β Scribed by Akdis, Cezmi A.; Blaser, Kurt
- Book ID
- 122644919
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 295 KB
- Volume
- 112
- Category
- Article
- ISSN
- 1097-6825
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Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, wh
H istamine plays a major role in allergic rhinitis. In susceptible individuals, allergen induces nasal mast cell degranulation and the release of histamine into the nasal mucosa. Histamine has been detected after controlled challenges with allergen and, when administered into the nasal cavity, elici