[Advances in Experimental Medicine and Biology] Histamine in Inflammation Volume 709 || Histamine in Allergic Rhinitis

✍ Scribed by Thurmond, Robin L.

• Book ID: 111694304
• Publisher: Springer US
• Year: 2010
• Weight: 191 KB
• Category: Article
• ISBN: 1441980563
• DOI: 10.1007/978-1-4419-8056-4_4

✦ Synopsis

H
istamine plays a major role in allergic rhinitis. In susceptible individuals, allergen induces nasal mast cell degranulation and the release of histamine into the nasal mucosa. Histamine has been detected after controlled challenges with allergen and, when administered into the nasal cavity, elicits signs and symptoms similar to those elicited by allergen. All four histamine receptors have been demonstrated in the nasal mucosa. The role of the four histamine receptors in the pathophysiology of allergic rhinitis are discussed. Antagonist Allergen Exposure Sneeze Pruritus Rhinorrhea Nasal Blockage Ref Astemizole Challenge (R) 66 Astemizole Ambient No effect (SS) 67 Chlorpheniramine Ambient No effect (SS) 68 Cetirizine Ambient 69 Cetirizine Ambient No effect (SS) 70 Cetirizine Challenge No effect (AR) 11