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HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

✍ Scribed by Stefano, Valeria Di; Blandino, Giovanni; Sacchi, Ada; Soddu, Silvia; D'Orazi, Gabriella


Book ID
110068728
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
251 KB
Volume
23
Category
Article
ISSN
0950-9232

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## Abstract We report that MDM2, a negative regulator of p53, can bind to EBNA‐5. Using GST pull‐down assay, immunoprecipitation, surface plasmon resonance and immunostaining of lymphoblastoid cells, we found that trimolecular complexes are formed between EBNA‐5, MDM2 and p53, where MDM2 serves as