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Highly stereoselective synthesis of substituted hydrindanes related to the antiepileptic drug topiramate

✍ Scribed by M.N. Greco; B.E. Maryanoff


Book ID
103408733
Publisher
Elsevier Science
Year
1993
Tongue
French
Weight
28 KB
Volume
34
Category
Article
ISSN
0040-4039

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ChemInform Abstract: Stereoselective Rou
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## Abstract Reaction of cyclopropanecarbaldehyde (I) with aryltitanium reagents, followed by tin‐catalyzed retro‐aldol—acetalization—lactonization sequence provides access towards γ‐aryllactones, e.g. (IV)/(V), with moderate to high diastereoselectivity.