Highly Stereoselective Intermolecular Oxy-Michael Addition Reaction to α,β-Unsaturated Malonate Esters
✍ Scribed by Buchanan, David J.; Dixon, Darren J.; Hernandez-Juan, Felix A.
- Book ID
- 119947948
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 82 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
Under a proper reaction condition, simple ester enolates add to d,e-unsaturated esters highly stereoselectively to give erythro or threoglutarates. Previously, we have shown that lithium enolates derived from simple monoesters react with fi,p-unsaturated esters to give glutarates in high yiela. 1)
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a-Lithiated phosphonates added to a&unsaturated t-butyl esters in 1,Gmanner giving anti-3,4-disubstituted-4-phosphorylbutanoates in high yields. /~~%~ylam%omethyl)phosphonates were prepared from dialkyl phosphite, dibenzylamine, and formaldehyde: See; R. Tyka, Tetrahedron Lett., 1970, 677.