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Highly stereoselective induction in the cobalt-mediated [2+2+2] cycloaddition of chiral phosphine oxides substituted linear enediynes

โœ Scribed by Franck Slowinski; Corinne Aubert; Max Malacria

Book ID
104261920
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
226 KB
Volume
40
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The cobalt(I)-catalyzed highly stereoselective [2+2+2] cyclization has been realized for the first time with chiral phosphine oxides substituted linear enediynes. Depending the substituents on the phosphorus atom, the cycloaddition was achieved with a level of diastereoseleetivity of 74%.

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ChemInform Abstract: Improvement of the Diastereoselectivity of the Cobalt-Mediated [2 + 2 + 2] Cycloaddition of Substituted Linear Enediynes.
โœ Franck Slowinski; Corinne Aubert; Max Malacria ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB ๐Ÿ‘ 1 views

Improvement of the Diastereoselectivity of the Cobalt-Mediated [2 + 2 + 2] Cycloaddition of Substituted Linear Enediynes. -Substituting the terminal triple bond or the double bond in the enediynes (I) with ester, phosphine oxide or sulfoxide groups improves the level of diastereoselectivity in the