ChemInform Abstract: Improvement of the Diastereoselectivity of the Cobalt-Mediated [2 + 2 + 2] Cycloaddition of Substituted Linear Enediynes.

✍ Scribed by Franck Slowinski; Corinne Aubert; Max Malacria

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 29 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199916110

✦ Synopsis

Improvement of the Diastereoselectivity of the Cobalt-Mediated [2 + 2 + 2] Cycloaddition of Substituted Linear Enediynes.

-Substituting the terminal triple bond or the double bond in the enediynes (I) with ester, phosphine oxide or sulfoxide groups improves the level of diastereoselectivity in the Co-mediated [2 + 2 + 2]cyclization to tricyclic products (III) and (IV).