𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Highly selective reactions of FK506 with diazomethane

✍ Scribed by A.J.F. Edmunds; K. Baumann; M. Grassberger; G. Schulz

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
290 KB
Volume
32
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Synthesis of ascomycin and FK 506 deriva
Synthesis of ascomycin and FK 506 derivatives with modified effector domain
✍ Peter Nussbaumer; Maximilian A. Grassberger; Gerhard Schulz πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 205 KB

Oxidation of the 22-hydrazone of ascomycin using manganese dioxide generates in situ the reactive 22-diazo intermediate, which decomposes to give ascomycin analogues with modified effector region. In dichloromethane several products are obtained, whereas in methanol a cyclopropane derivative is gene

Use of mixed lymphocyte reaction to iden
Use of mixed lymphocyte reaction to identify subimmunosuppressive FK-506 levels in mice
✍ Ramsay A. Ellis; Michael J. Brenner; Susan E. Mackinnon; Terence M. Myckatyn; Da πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 273 KB

## Abstract The immunosuppressive agent FK‐506 has a well‐described neuroregenerative effect that is mediated by a mechanism independent of calcineurin inhibition. FK‐506 levels that fall below the threshold for immunosuppression could therefore potentially enhance nerve regeneration while minimizi