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Highly selective, kinetically controlled enolate formation using lithium dialkylamides in the presence of trimethylchlorosilane

โœ Scribed by E.J. Corey; Andrew W. Gross


Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
210 KB
Volume
25
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


Enantioselective alkylation of lactams a
โœ Jun-ichi Matsuo; Shu Kobayashi; Kenji Koga ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 210 KB

Enantioselective alkylation of lactams and lactones can be realized up to 98% ee by deprotonation with a chiral tetradentate lithium amide (4b) in the presence of lithium bromide, and subsequent alkylation with active alkylating agents in non-chelating solvents.