Enantioselective alkylation of lactams a
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Jun-ichi Matsuo; Shu Kobayashi; Kenji Koga
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Article
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1998
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Elsevier Science
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French
โ 210 KB
Enantioselective alkylation of lactams and lactones can be realized up to 98% ee by deprotonation with a chiral tetradentate lithium amide (4b) in the presence of lithium bromide, and subsequent alkylation with active alkylating agents in non-chelating solvents.