✍ Scribed by Lutz F. Tietze; Christoph Wegner; Christian Wulff
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The facial selective allylation of alkyl methyl ketones 1a-f in even for the allylation of ethyl methyl ketone. The ethers 8 and 9, which contain a phenyl group at C-1 of the amino the presence of chiral 2-amino alcohol derivatives 2a-p by reaction with allylsilane 3 and a catalytic amount of TfOH to alcohol moiety, can be cleaved to give the corresponding homoallylic alcohols 5 by reduction with sodium or lithium give the tertiary homoallylic ethers 8a-o and 9a-e is described. The best results were obtained with the 2-amino in liquid ammonia. alcohol derivative 2p which affords a stereoselectivity of 18:1
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A series of acyclic and cyclic enol derivatives 1 has been transformed into the corresponding α-amino-functionalized ketones 2 by means of enantioselective catalytic aziridination with chiral Cu complexes, prepared in situ from [Cu(MeCN)4]PF 6 and the optically active ligands 3, by using (N-tosylimi
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