✦ LIBER ✦
Catalytic Asymmetric Aziridination of Enol Derivatives in the Presence of Chiral Copper Complexes to give Optically Active α-Amino Ketones
✍ Scribed by Waldemar Adam; Konrad Johann Roschmann; Chantu Ranjan Saha-Möller
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 292 KB
- Volume
- 2000
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
A series of acyclic and cyclic enol derivatives 1 has been transformed into the corresponding α-amino-functionalized ketones 2 by means of enantioselective catalytic aziridination with chiral Cu complexes, prepared in situ from [Cu(MeCN)4]PF 6 and the optically active ligands 3, by using (N-tosylimino)iodobenzene (PhINTs) as a nitrogen source. The best enantioselectivities (ee values of up to 52%) have been achieved for the electronically deactivated enol acetate