Highly Regioselective Friedel—Crafts Alkylation of Indoles with α,β-Unsaturated N-Acylbenzotriazoles.
✍ Scribed by Xuefei Zou; Xiaoxia Wang; Cungui Cheng; Lichun Kong; Hui Mao
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 22 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract magnified image The Lewis base‐Lewis base bifunctional catalytic system has been developed and successfully applied to the asymmetric Friedel–Crafts alkylation of indoles with α,β‐unsaturated aldehydes. The reactions are promoted by chiral diphenylprolinol trimethylsilyl ether in the p