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Highly regioselective additions of certain 2-lithio-1,3-dithianes to conjugated ketones

โœ Scribed by Paul C. Ostrowski; Vinayak V. Kane

Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
226 KB
Volume
18
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Since the late 1960's, considerable effort has been devoted towards the discovery of useful synthetic equivalents of the acyl anion'.

Among the most widely used reagents are the metalated 1,3-dithiane derivatives2. The Michael addition of these acyl anion equivalents to a,B-unsaturated ketones is a reaction of particular synthetic utility, which has received significant attention and generally affords 1,2-addition products2. However, two recent publications have

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