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Highly rapid and direct synthesis of monoacylated piperazine derivatives from carboxylic acids under mild conditions

✍ Scribed by B.P Bandgar; S.S Pandit

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 192 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00684-1

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✦ Synopsis

A series of monoacylated piperazine derivatives were obtained by the reaction of carboxylic acids with 2-chloro-4,6dimethoxy-1,3,5-triazine in dichloromethane at room temperature. Good to excellent yields, short reaction times and mild reaction conditions are important features of this methodology.

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