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Highly polymorphic region of the human prothrombin (F2) gene

✍ Scribed by Hiroyuki Iwahana; Katsuhiko Yoshimoto; Mitsuo Itakura

Publisher
Springer
Year
1992
Tongue
English
Weight
131 KB
Volume
89
Category
Article
ISSN
0340-6717

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✦ Synopsis

We have found a highly polymorphic region in the human prothrombin gene. Our sequence differed from that previously reported at as many as 6 positions in a 225-bp stretch spanning exon 6 and its flanking regions; four of these positions were related to endonuclease restriction sites for AluI, HpaII(MspI), MboII, and NcoI. AluI and HpaII digested all alleles of the Japanese tested. MboII and NcoI restriction fragment length polymorphisms are highly heterozygous and not in linkage disequilibrium; they thus serve as good human DNA markers.

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