Highly Enantioselective Synthesis of γ-Hydroxy-α,β-acetylenic Esters Catalyzed by a β-Sulfonamide Alcohol.
✍ Scribed by Li Lin; Xianxing Jiang; Weixia Liu; Li Qiu; Zhaoqing Xu; Jiangke Xu; Albert S. C. Chan; Rui Wang
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 28 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
g-Hydroxy-a,b-acetylenic esters containing three adjacent and structurally very different functional groups are very useful in the synthesis of highly functionalized organic molecules. [1, 2] This class of compound is normally prepared by treatment of an alkyl propiolate with nBuLi at À78 8C
The formation of 4-alkoxy-2(5H)-furan-A C H T U N G T R E N N U N G ones was achieved via tandem alkoxylation/lactonization of g-hydroxy-a,b-acetylenic esters catalyzed by 2 mol% of [2,6-bis(diisopropylphenyl)imidazol-2-ylidine]gold bis(trifluoromethanesulfonyl)imidate