Highly enantioselective synthesis of α-fluoro-α-nitro esters via organocatalyzed asymmetric Michael addition
✍ Scribed by Hai-Feng Cui; Peng Li; Xiao-Wei Wang; Zhuo Chai; Ying-Quan Yang; Yue-Peng Cai; Shi-Zheng Zhu; Gang Zhao
- Book ID
- 108283460
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 318 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0040-4020
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## Abstract An organocatalytic, highly enantioselective addition of 1‐fluoro‐1‐nitro(phenylsulfonyl)methane to α,β‐unsaturated aldehydes is reported. The reaction is simply catalyzed by secondary amines and furnishes the corresponding fluorinated derivatives in good yields, with moderate diastereos