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Highly Enantioselective Synthesis of α-Stereogenic Esters through Catalytic Asymmetric Michael Addition of 4-Oxo-4-arylbutenoates

✍ Scribed by Zhen Wang; Donghui Chen; Zhigang Yang; Sha Bai; Xiaohua Liu; Lili Lin; Xiaoming Feng


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
327 KB
Volume
16
Category
Article
ISSN
0947-6539

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## Abstract An organocatalytic enantioselective Michael addition of 2‐hydroxy‐1,4‐naphthoquinone to β,γ‐unsaturated α‐oxo esters has been developed. The process was promoted by bifunctional chiral amine derived squaramides according to a hydrogen‐bonding mediated activation mechanism and afforded t