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Highly Enantioselective Synthesis of Cyclopropylamine Derivatives via Ru(II)-Pheox-Catalyzed Direct Asymmetric Cyclopropanation of Vinylcarbamates

✍ Scribed by Chanthamath, Soda; Nguyen, Dao Thi; Shibatomi, Kazutaka; Iwasa, Seiji


Book ID
118733808
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
534 KB
Volume
15
Category
Article
ISSN
1523-7060

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A short and efficient enantioselective synthesis of (R)-(-)-baclofen, a selective GABA B agonist has been described with an overall yield of 26% and 90% ee. Ru(II)-(S)-BINAP catalyzed asymmetric hydrogenations of C C and C O groups constitute the key steps in introducing stereogenic centers into the