Enantioselective synthesis of (R)-(−)-baclofen via Ru(II)–BINAP catalyzed asymmetric hydrogenation

✍ Scribed by Vinay V. Thakur; Milind D. Nikalje; A. Sudalai

• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 206 KB
• Volume: 14
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(03)00024-7

✦ Synopsis

A short and efficient enantioselective synthesis of (R)-(-)-baclofen, a selective GABA B agonist has been described with an overall yield of 26% and 90% ee. Ru(II)-(S)-BINAP catalyzed asymmetric hydrogenations of C C and C O groups constitute the key steps in introducing stereogenic centers into the molecule.