✦ LIBER ✦

Highly enantioselective synthesis of anti aryl β-hydroxy α-amino esters via DKR transfer hydrogenation

✍ Scribed by Zhuqing Liu; C.Scott Shultz; Candice A. Sherwood; Shane Krska; Peter G. Dormer; Richard Desmond; Claire Lee; Edward C. Sherer; Joseph Shpungin; James Cuff; Feng Xu

Book ID: 104098915
Publisher: Elsevier Science
Year: 2011
Tongue: French
Weight: 456 KB
Volume: 52
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2011.01.146

No coin nor oath required. For personal study only.

✦ Synopsis

An efficient preparation of highly enantiomerically enriched aryl b-hydroxy a-amino esters via dynamic kinetic resolution (DKR), asymmetric transfer hydrogenation of a-amino b-keto esters is described. The anti b-hydroxyl a-amino esters were obtained both in high yields and high diasteroselectivity. The observed high anti selectivity is inconsistent with the previous results in literature. The absolute stereochemistry of the aryl b-hydroxy a-amino esters was unambiguously confirmed via chemical derivatization as well as Vibrational Circular Dichroism (VCD) techniques.

📜 SIMILAR VOLUMES

ChemInform Abstract: Highly Enantioselec

ChemInform Abstract: Highly Enantioselective Synthesis of anti Aryl β-Hydroxy α-Amino Esters via DKR Transfer Hydrogenation.

✍ Zhuqing Liu; et al. et al. 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 40 KB 👁 1 views

ChemInform Abstract: Enantioselective Sy

ChemInform Abstract: Enantioselective Synthesis of anti-β-Hydroxy-α-amido Esters via Transfer Hydrogenation.

✍ Brinton Seashore-Ludlow; Piret Villo; Christine Haecker; Peter Somfai 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

Enantioselective synthesis of anti-β-ami

Enantioselective synthesis of anti-β-amido-α-hydroxy esters via asymmetric transfer hydrogenation coupled with dynamic kinetic resolution

✍ Villacrez, Marvin; Somfai, Peter 📂 Article 📅 2013 🏛 Elsevier Science 🌐 French ⚖ 461 KB

Enantioselective Synthesis of anti-β-Hyd

Enantioselective Synthesis of anti-β-Hydroxy-α-Amido Esters by Asymmetric Transfer Hydrogenation in Emulsions

✍ Brinton Seashore-Ludlow; Piret Villo; Prof. Peter Somfai 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 349 KB

Asymmetric Synthesis of anti -β-Amino-α-

Asymmetric Synthesis of anti -β-Amino-α-Hydroxy Esters via Dynamic Kinetic Resolution of β-Amino-α-Keto Esters

✍ Goodman, C. Guy; Do, Dung T.; Johnson, Jeffrey S. 📂 Article 📅 2013 🏛 American Chemical Society 🌐 English ⚖ 330 KB

Catalytic Asymmetric Synthesis of β-Hydr

Catalytic Asymmetric Synthesis of β-Hydroxy-α-amino Acids: Highly Enantioselective Hydrogenation of β-Oxy-α-acetamidoacrylates

✍ Kuwano, Ryoichi; Okuda, Satoshi; Ito, Yoshihiko 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 65 KB