A catalytic highly enantioselective (99% ee) preparation of N-tert-butyloxycarbonyl-(2S,3S)-3-hydroxy-2-phenyl-piperidine and N-tert-butyloxycarbonyl-(2S)-2-phenyl-piperidin-3-one was developed using an intramolecular epoxide opening followed by ring expansion. The cis-epoxide starting material was
✦ LIBER ✦
Highly Enantioselective Synthesis of 3-Hydroxy-2-phenylpiperidine via the Sharpless AD-Reaction
✍ Scribed by Stadler, Heinz; Bös, Michael
- Book ID
- 125488279
- Publisher
- Japan Institute of Heterocyclic Chemistry
- Year
- 1999
- Tongue
- English
- Weight
- 116 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0385-5414
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