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Highly Enantioselective One-Pot, Three-Component Imino-Reformatsky Reaction

✍ Scribed by Pier Giorgio Cozzi; Eleonora Rivalta

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 333 KB
Volume: 117
Category: Article
ISSN: 0044-8249
DOI: 10.1002/ange.200462757

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## Abstract The highly enantioselective organocatalytic domino aza‐Michael/aldol reaction is presented. The unprecedented, chiral amine‐catalyzed asymmetric domino reactions between 2‐aminobenzaldehydes and α,β‐unsaturated aldehydes proceed with excellent chemo‐ and enantioselectivity to give the c