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Highly enantioselective cascade synthesis of spiropyrazolones

✍ Scribed by Zea, Alex; Alba, Andrea-Nekane R.; Mazzanti, Andrea; Moyano, Albert; Rios, Ramon

Book ID
120081607
Publisher
Royal Society of Chemistry
Year
2011
Tongue
English
Weight
255 KB
Volume
9
Category
Article
ISSN
1477-0520

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## Abstract The synthesis of spiro compounds through a Michael–Michael–aldol reaction is reported. The reaction affords spiropyrazolone derivatives in good yields, in almost diastereo‐ and enantiopure form, and is catalyzed by diphenylprolinol derivatives. The reaction showed strong nonlinear effec

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## Abstract The title compounds are obtained through a Michael—Michael‐aldol reaction in good yields and with high diastereo‐ and enantioselectivity.

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