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Highly enantio- and diastereoselective synthesis of α-trifluoromethyldihydropyrans using a novel bifunctional piperazine-thiourea catalyst

✍ Scribed by Li, Peng; Chai, Zhuo; Zhao, Sheng-Li; Yang, Ying-Quan; Wang, Hai-Feng; Zheng, Chang-Wu; Cai, Yue-Peng; Zhao, Gang; Zhu, Shi-Zheng


Book ID
120300867
Publisher
Royal Society of Chemistry
Year
2009
Tongue
English
Weight
529 KB
Volume
47
Category
Article
ISSN
1359-7345

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Highly Enantioselective Synthesis of α-T
✍ Peng Li; Gang Zhao; Shizheng Zhu 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 1 views

## Abstract An enantioselective Michael addition of ethyl 4,4,4‐trifluoro‐3‐oxobutanoate to __α__,__β__‐unsaturated ketone esters using a chiral alkyl‐substituted thiourea catalyst is reported. Excellent levels of stereo‐induction (up to 98% __ee__) under mild reaction conditions were obtained to a