Highly Efficient Threonine-Derived Organocatalysts for Direct Asymmetric Aldol Reactions in Water.
β Scribed by Xiaoyu Wu; Zhaoqin Jiang; Han-Ming Shen; Yixin Lu
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 28 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
## Abstract The catalyst is easily prepared in a single step, only 5 mol% are used, it is easily recovered and reused without significant loss of activity or stereoselectivity and the aldol reaction can be performed on a large scale.
## Abstract A series of novel Lβproline derived thioamides has been synthesised. They have been evaluated as organocatalysts in the direct asymmetric aldol reaction for the first time. Thioamides exhibit catalytic ability higher than proline itself and the model aldol reaction of 4βcyanobenzaldehyd