Highly Efficient Enzymatic Synthesis of 2-Monoacylglycerides and Structured Lipids and their Production on a Technical Scale
โ Scribed by Jan Pfeffer; Andreas Freund; Rachid Bel-Rhlid; Carl-Erik Hansen; Matthias Reuss; Rolf D. Schmid; Steffen C. Maurer
- Book ID
- 107487861
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 203 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0024-4201
No coin nor oath required. For personal study only.
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## Abstract Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 6โformylโ2,3โdimethoxybenzoic acid and secondary amines (dibenzylโ or benzyl(isopropyl)amine) in the presence of silica nanoparticles (silica NPs, __ca.__ 70โ nm) proceeds smoothly at room temperature
## Abstract Multicomponent reaction of oโformylbenzoic acid derivative (I) with secondary amines (III) and isocyanides (II) proceeds smoothly in the presence of silica nanoparticles under neat conditions to give dihydroisoindolone derivatives (IV) in good yields.