Highly Efficient Conjugate Addition of Amines to Electron Deficient Alkenes Catalyzed by KF Supported on Metal Oxides

✍ Scribed by Xuezheng LIANG; Jing ZHANG; Shaohua BAO; Jianguo YANG

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 57 KB
• Volume: 27
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.200990204

✦ Synopsis

Abstract

A novel efficient procedure has been developed for the conjugate addition of amines to electron deficient alkenes. A series of KF supported on different carriers have been synthesized for the conjugate addition amines to alkenes. After optimizing the reaction conditions, KF/MgO was chosen as the most efficient catalyst for the reactions. The results showed that the catalyst was very efficient for the conjugate addition of amines to electron deficient alkenes with excellent yields in several minutes. Operational simplicity, no need of any solvent, low cost of the catalyst used, high yields, reusability, excellent chemoselectivity and wide applicability are the key features of this methodology.