Novel Synthetic Methodologies. Part 120. Efficient Conjugate Addition of 1H-Indoles to Electron-Deficient Olefins Catalyzed by Silica-Supported Sodium Hydrogen Sulfate (NaHSO4×SiO2).

Efficient Conjugate Addition of 1H-Indol

Efficient Conjugate Addition of 1H-Indoles to Electron-Deficient Olefins Catalyzed by Silica-Supported Sodium Hydrogen Sulfate (NaHSO4 ⋅ SiO2)

✍ Biswanath Das; Nikhil Chowdhury; K. Damodar; K. Ravinder Reddy 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 German ⚖ 77 KB 👁 1 views

## Abstract A simple, mild, rapid, and highly efficient method for the conjugate addition of 1__H__‐indoles to electron‐deficient olefins has been developed using NaHSO~4~ ⋅ SiO~2~ as heterogeneous catalyst. The conversion proceeds at room temperature, and the corresponding __Michael__ adducts are