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Highly Efficient and Regioselective Platinum(II)-Catalyzed Tandem Synthesis of Multiply Substituted Indolines and Tetrahydroquinolines

✍ Scribed by Xin-Yuan Liu; Chi-Ming Che

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 332 KB
Volume: 48
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200805383

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✦ Synopsis

Abstract

A special advantage: The platinum(II)‐catalyzed tandem cyclization of aminoalkynes with 1,3‐diketones offers a new and highly efficient method for the synthesis of indolines and tetrahydroquinolines (see scheme; M.S.=molecular sieves). This transformation affords good to excellent product yields with high regio‐ and chemoselectivity under mild reaction conditions.magnified image

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