Highly effective and enantioselective Phospho-Aldol reaction of diphenyl phosphite with N-alkylated isatins catalyzed by quinine

✍ Scribed by Lin Peng; Liang-Liang Wang; Jian-Fei Bai; Li-Na Jia; Qing-Chuan Yang; Qing-Chun Huang; Xiao-Ying Xu; Li-Xin Wang

• Book ID: 104098794
• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 413 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.12.101

✦ Synopsis

Cinchona alkaloids were first successfully reported to promote enantioselective Phospho-Aldol reaction of diphenyl phosphite to a variety of N-alkylated isatin derivatives in good to excellent yields (up to 99%) and moderate to good enantioselectivities (up to 73% ee) almost in no time.