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Highly diastereoselective hydrocyanation of .beta.-keto sulfoxides: synthesis of enantiomerically pure cyanohydrin derivatives

✍ Scribed by Garcia Ruano, Jose L.; Martin Castro, Ana M.; Rodriguez, Jesus H.


Book ID
127119139
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
1017 KB
Volume
57
Category
Article
ISSN
0022-3263

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Enantiomerically pure acylketene acetals were employed to generate a homochiral p-keto ketal through a highly diastereoselective lithium enolate quench. The fi-keto ketal, which was also prepared through a desymmetrization ketulizution reaction on a meso dione, was employed in the synthesis of the i