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Highly Diastereoselective Henry Reaction of Nitro Compounds with Chiral Derivatives of Glyoxylic Acid.

โœ Scribed by Iwona Kudyba; Jerzy Raczko; Zofia Urbanczyk-Lipkowska; Janusz Jurczak


Publisher
John Wiley and Sons
Year
2004
Weight
38 KB
Volume
35
Category
Article
ISSN
0931-7597

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Highly diastereoselective synthesis of a
โœ Yong-Jun Chen; Fei Lei; Li Liu; Dong Wang ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 185 KB

Optically active a-arylglycine derivatives were synthesized by Brรธnsted acid (TFA)-promoted Friedel-Crafts reaction of various phenols with chiral cyclic glyoxylate imines (2a -c), followed by deprotection with Pd(OH) 2 /C under H 2 . The diastereoselectivities of the initially formed F-C reaction p