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Highly Diastereoselective Friedel—Crafts Reaction of Furans with 8-Phenylmenthyl Glyoxylate.

✍ Scribed by Piotr Kwiatkowski; Jakub Majer; Wojciech Chaladaj; Janusz Jurczak


Publisher
John Wiley and Sons
Year
2007
Weight
35 KB
Volume
38
Category
Article
ISSN
0931-7597

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Highly diastereoselective synthesis of a
✍ Yong-Jun Chen; Fei Lei; Li Liu; Dong Wang 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 185 KB

Optically active a-arylglycine derivatives were synthesized by Brønsted acid (TFA)-promoted Friedel-Crafts reaction of various phenols with chiral cyclic glyoxylate imines (2a -c), followed by deprotection with Pd(OH) 2 /C under H 2 . The diastereoselectivities of the initially formed F-C reaction p