Highly Diastereoselective Epimerization: Stereodivergent Synthesis of α-Hydroxy-β-amino Isopentanoic Acid
✍ Scribed by Seo, Woo Duck; Curtis-Long, Marcus J.; Ryu, Young Bae; Lee, Jin Hwan; Yang, Min Suk; Lee, Woo Song; Park, Ki Hun
- Book ID
- 115513299
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 83 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0022-3263
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Reported here is an efficient procedure for enantio-and diastereoselective synthesis of pure b-amino acids that display a tert-hydroxyl functionality in the a-position. Key steps include a catalytic asymmetric aldol reaction and a modified Curtius rearrangement to form oxazolidinone intermediates, w
Alkylation / Oxazolines / anti-α-Alkyl α-hydroxy β-amino acids / Lithium dianion / Penicillin G acylase As part of an ongoing project concerning the synthesis of conditions, affording in quantitative yield the corresponding hydroxy amides. The starting (R)-3-amino-3-phenyl-enantiomerically pure α-hy