Highly Diastereo- and Enantioselective Mukaiyama Aldol Reactions Catalyzed by Hydrogen Bonding
β Scribed by Jeff D. McGilvra; Aditya K. Unni; Kriti Modi; Viresh H. Rawal
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 169 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The CoCl~2~/Lβproline (1:2) system was found to be an excellent catalyst for direct aldol reactions. Excellent yields (up to 93β%) and a significant improvement in diastereoselectivity (__anti__/__syn__ up to 45:1) as well as enantioselectivity (up to more than 99β% __ee__) compared wit
The development of efficient catalytic asymmetric methodologies for the construction of chiral, nonracemic tertiary alcohols is currently a challenging research area of interest, [1] and a few asymmetric catalytic methods dealing with this demanding task have been described. [2][3][4][5][6][7] Despi