Highly Diastereo- and Enantioselective Copper-Catalyzed Domino Reduction/Aldol Reaction of Ketones with Methyl Acrylate

✍ Scribed by Julia Deschamp; Olivier Chuzel; Jérôme Hannedouche; Olivier Riant

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 124 KB
• Volume: 45
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200503791

✦ Synopsis

The development of efficient catalytic asymmetric methodologies for the construction of chiral, nonracemic tertiary alcohols is currently a challenging research area of interest, [1] and a few asymmetric catalytic methods dealing with this demanding task have been described. [2][3][4][5][6][7] Despite excellent progress in the field of metal-catalyzed enantioselective nucleophilic addition to ketones, only limited success has

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