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Highly Diastereo- and Enantioselective Direct Aldol Reactions of Aldehydes and Ketones Catalyzed by Siloxyproline in the Presence of Water

โœ Scribed by Seiji Aratake; Takahiko Itoh; Tsubasa Okano; Norio Nagae; Tatsunobu Sumiya; Mitsuru Shoji; Yujiro Hayashi


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
454 KB
Volume
13
Category
Article
ISSN
0947-6539

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## Abstract A combination of zinc triflate and chiral __C~2~__โ€symmetrical prolinamide ligand leads to high enantioselectivities in direct aldol reactions essentially assisted by water. The presence of 5 molโ€‰% of the catalyst affords an asymmetric intermolecular aldol reaction between unmodified ke