The development of efficient catalytic asymmetric methodologies for the construction of chiral, nonracemic tertiary alcohols is currently a challenging research area of interest, [1] and a few asymmetric catalytic methods dealing with this demanding task have been described. [2][3][4][5][6][7] Despi
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Highly Diastereo- and Enantioselective Direct Aldol Reactions of Aldehydes and Ketones Catalyzed by Siloxyproline in the Presence of Water
โ Scribed by Seiji Aratake; Takahiko Itoh; Tsubasa Okano; Norio Nagae; Tatsunobu Sumiya; Mitsuru Shoji; Yujiro Hayashi
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 454 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0947-6539
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## Abstract A combination of zinc triflate and chiral __C~2~__โsymmetrical prolinamide ligand leads to high enantioselectivities in direct aldol reactions essentially assisted by water. The presence of 5 molโ% of the catalyst affords an asymmetric intermolecular aldol reaction between unmodified ke