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Higher Risk of Mismatch Repair-Deficient Colorectal Cancer in α1-Antitrypsin Deficiency Carriers and Cigarette Smokers

✍ Scribed by Ping Yang; Julie M. Cunningham; Kevin C. Halling; Timothy G. Lesnick; Lawrence J. Burgart; Elaine M. Wiegert; Eric R. Christensen; Noralane M. Lindor; Jerry A. Katzmann; Stephen N. Thibodeau


Book ID
115639767
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
63 KB
Volume
71
Category
Article
ISSN
1096-7192

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## Abstract Rare inherited mutations in the __mutL homolog 1__ (__MLH1__) DNA mismatch repair gene can confer an increased susceptibility to colorectal cancer (CRC) with high penetrance where disease frequently develops in the proximal colon. The core promoter of __MLH1__ contains a common single n