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Higher Frequency of Point Mutations in the c-K-ras2Gene in Human Colorectal Adenomas with Severe Atypia than in Carcinomas

โœ Scribed by Ando, Masayuki ;Maruyama, Michio ;Oto, Michiei ;Takemura, Katsuji ;Endo, Mitsuo ;Yuasa, Yasuhito


Book ID
108579278
Publisher
Wiley (Blackwell Publishing)
Year
1991
Tongue
English
Weight
265 KB
Volume
82
Category
Article
ISSN
0910-5050

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## BACKGROUND. The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in sit