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High-voltage paper electrophoresis for characterization of drug metabolites

โœ Scribed by Walter D. Conway; Vijay K. Batra; Alan Abramowitz

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
833 KB
Volume
62
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

Ahstraet 0 Methodology for obtaining reproducible measurements of the relative mobility of organic compounds over pH 2-12 using high-voltage paper electrophoresis is described. Use of the method for the elucidation of some structural features of simple molecules is illustrated by applying it to the characterization of metabolites of drugs excreted in the urine and bile of rats. The compounds studied included p-nitrophenol, 1-naphthol, salicylic acid, 4-nitrocatechol, probenecid, phenol red, and their metabolites.

Keyphrases 0 Mobility-pH profiles, drug metabolites-determined using high-voltage paper electrophoresis 0 Metabolites-charac-teri7ed using high-voltage paper electrophoresis 0 Structure characterization-mobility-pH profiles of drug metabolites determined using high-voltage paper electrophoresis 0 Paper electrophoresis, high voltage-determination of mobility--pH profiles for drug metabolites * Shnndon modcl 2550.

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