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High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic Arrays

✍ Scribed by Jun Wang; Min Lin; Andrew Crenshaw; Amy Hutchinson; Belynda Hicks; Meredith Yeager; Sonja Berndt; Wen-Yi Huang; Richard B Hayes; Stephen J Chanock; Robert C Jones; Ramesh Ramakrishnan

Book ID
115003117
Publisher
BioMed Central
Year
2009
Tongue
English
Weight
868 KB
Volume
10
Category
Article
ISSN
1471-2164

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Background: Genetic diversity can help explain disease susceptibility and differential drug response. The most common type of variant is the single nucleotide polymorphism (SNP). We present a low-cost, high throughput assay for SNP genotyping. Methods: The assay uses oligonucleotide probes covalentl