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High-throughput capillary electrophoresis frontal analysis method for the study of drug interactions with human serum albumin at near-physiological conditions

✍ Scribed by Juan J. Martínez-Pla; María A. Martínez-Gómez; Yolanda Martín-Biosca; Salvador Sagrado; Rosa M. Villanueva-Camañas; Maria J. Medina-Hernández


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
149 KB
Volume
25
Category
Article
ISSN
0173-0835

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Capillary electrophoresis frontal analysis was applied to 12 low molecular weight compounds including 8 drug substances displaying a range of different properties with respect to binding affinity, binding location, structure, lipophilicity, charge at physiological pH, and electrophoretic mobility. I