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High-throughput approaches to the quantitative analysis of ketoconazole, a potent inhibitor of cytochrome P450 3A4, in human plasma

โœ Scribed by L. Ramos; N. Brignol; R. Bakhtiar; T. Ray; L. M. Mc Mahon; F. L. S. Tse


Book ID
118280981
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
318 KB
Volume
14
Category
Article
ISSN
0951-4198

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โœ Inhou Chu; Leonard Favreau; Tony Soares; Chin-chung Lin; Amin A. Nomeir ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 166 KB ๐Ÿ‘ 2 views

In the early stage of drug discovery, thousands of new chemical entities (NCEs) may be screened before a single drug candidate can be identified for development. In order to accelerate the drug discovery process, we have developed higher-throughput enzyme assays to evaluate the inhibition of cytochr