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High Sensitivity and Fragmentation Specificity in the Analysis of Drug−DNA Adducts by Electrospray Tandem Mass Spectrometry

✍ Scribed by Iannitti, Paula; Sheil, Margaret M.; Wickham, Geoffrey


Book ID
127000929
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
64 KB
Volume
119
Category
Article
ISSN
0002-7863

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## Abstract High‐performance liquid chromatography (HPLC) was combined with electrospray ionization tandem mass spectrometry (ESI‐MS/MS) to develop a sensitive and selective method for the quantitative measurement of __N__^7^‐(2‐hydroxyethyl)guanine (__N__^7^‐HEG) adducts in DNA obtained from ethyl