High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA

The High-Resolution Solution Structure o

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 2 views

Most of the drugs available today for the treatment of cancer are based on the inhibition of cell proliferation and induction of cell death by apoptosis. At the molecular level, the majority of cytotoxic agents interfere with DNA function. However, a prominent subclass of compounds, including paclit

The High-Resolution Solution Structure o

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 2 views

Most of the drugs available today for the treatment of cancer are based on the inhibition of cell proliferation and induction of cell death by apoptosis. At the molecular level, the majority of cytotoxic agents interfere with DNA function. However, a prominent subclass of compounds, including paclit

Solution Structural Study of a DNA Duple

Solution Structural Study of a DNA Duplex Containing the Guanine-N7 Adduct Formed by a Cytotoxic Platinum−Acridine Hybrid Agent †,‡

✍ Baruah, Hemanta; Wright, Marcus W.; Bierbach, Ulrich 📂 Article 📅 2005 🏛 American Chemical Society 🌐 English ⚖ 475 KB

Consequences of Replacing the DNA 3‘-Oxy

Consequences of Replacing the DNA 3‘-Oxygen by an Amino Group: High-Resolution Crystal Structure of a Fully Modified N3‘ → P5‘ Phosphoramidate DNA Dodecamer Duplex †

✍ Tereshko, Valentina; Gryaznov, Sergei; Egli, Martin 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 273 KB

Titelbild: The High-Resolution Solution

Titelbild: The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents (Angew. Chem. 22/2003)

✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 22 KB 👁 2 views

**Leistungsstarke Tumortherapeutika** der Epothilon‐Familie wirken durch Bindung an Tubulin und Beeinflussung der Microtubuli‐Entwicklung. Bisher sind keine hochaufgelösten Strukturen von Tubulin‐Epothilon‐Komplexen verfügbar, doch ließen sich NMR‐spektroskopisch zwei größere Konformationsänderungen

Cover Picture: The High-Resolution Solut

Cover Picture: The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents (Angew. Chem. Int. Ed. 22/2003)

✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 22 KB 👁 2 views