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Cover Picture: The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents (Angew. Chem. Int. Ed. 22/2003)

✍ Scribed by Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas Schupp; Frank Petersen; Dieter Schinzer; Karl-Heinz Altmann; Christian Griesinger

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
22 KB
Volume
42
Category
Article
ISSN
0044-8249

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Titelbild: The High-Resolution Solution
Titelbild: The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents (Angew. Chem. 22/2003)
✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 22 KB 👁 1 views

**Leistungsstarke Tumortherapeutika** der Epothilon‐Familie wirken durch Bindung an Tubulin und Beeinflussung der Microtubuli‐Entwicklung. Bisher sind keine hochaufgelösten Strukturen von Tubulin‐Epothilon‐Komplexen verfügbar, doch ließen sich NMR‐spektroskopisch zwei größere Konformationsänderungen

The High-Resolution Solution Structure o
The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents
✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 2 views

Most of the drugs available today for the treatment of cancer are based on the inhibition of cell proliferation and induction of cell death by apoptosis. At the molecular level, the majority of cytotoxic agents interfere with DNA function. However, a prominent subclass of compounds, including paclit

The High-Resolution Solution Structure o
The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents
✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 2 views

Most of the drugs available today for the treatment of cancer are based on the inhibition of cell proliferation and induction of cell death by apoptosis. At the molecular level, the majority of cytotoxic agents interfere with DNA function. However, a prominent subclass of compounds, including paclit