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High-resolution methylation analysis of the BRCA1 promoter in ovarian tumors

✍ Scribed by Cathy B. Wilcox; Bora E. Baysal; Holly H. Gallion; Mary A. Strange; Julie A. DeLoia


Book ID
113512650
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
815 KB
Volume
159
Category
Article
ISSN
0165-4608

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## Abstract ## BACKGROUND Microsatellite instability (MSI) has been reported in endometrial carcinoma (EC) and in colorectal carcinoma (CRC), primarily as a result of defective DNA mismatch repair (MMR). The MMR gene __hMLH1__ commonly is inactivated in both EC and CRC. In the current study, epige